姓名:张洁
出生年月:1982年7月
职称:教授
邮箱:
研究方向:
天然有机化学
有机小分子结构修饰及活性研究
个人简介
张洁,女,天津大学工学博士,yl6809永利官网yl6809永利官网教授,硕士生导师。yl6809永利官网“3152”中青年骨干教师,优秀青年教师。
科研项目
1.自治区重大科技专项子任务:新疆优势畜产品质量安全测试分析与基础数据库构建,(2022A02006-5-2, 40万) ,2022.12-2025.12,主持。
2.大蒜素原料药杂质制备与检测,企业委托,15万元,2021-2023,主持。
3.抗包虫体内样品的合成(4),企业委托,11.6万元, 2020,主持。
4.抗包虫候选药物H-2-168的中试合成工艺优化,yl6809永利官网创新发展项目,2019-2021, 15万元,主持。
5.抗包虫体内样品的合成(3),企业委托, 2019,8.4万元,主持。
6.抗包虫体内样品的合成(2),企业委托, 2018,3.3万元,主持。
7.去氢骆驼蓬碱结构改造与抗肿瘤活性研究,企业委托,2016-2018,15.5万元 主持。
8.抗包虫体内样品的合成,企业委托,2017-2018,3.2万元,主持。
9.药西瓜中葫芦素类化合物的分离、纯化与活性研究(2013ZRKXYQ-YD01),优秀青年科技人才培育计划,2014-2015,主持。
10.维药药西瓜化学成分的分离与抗肿瘤活性研究(RCZX201120),校高层次人才启动基金,2012-2013,主持。
11.有机催化氰化反应研究(2011ZRKXTD-0404),校团队创新项目课题,2012-2014,主持。
代表性论文:
1.Zhu, Siyu; Huo, Xinyu; Ma, Qin; Chen, Wei; Zhang, Jie*; Guo, Liang*. Design, Synthesis, and Antitumor Activity of β-Carboline-Benzimidazole Hybrids. Chin. J. Org. Chem. 2022, 42, 1129-1135.
2.Sun, Yue; Guo, Liang; Fan, Wenxi; Chen, Wei; Zhang, Jie*; Dai, Bin. Synthesis, Crystal Structure and Antitumor Activity of Novel 5-Chloro-β-carboline Derivatives. Chin. J. Org. Chem. 2021, 41, 400-401.
3.Guo, Liang; Chen, Xiaofei; Chen, Wei; Ma, Qin; Fan, Wenxi; Zhang, Jie*; Dai, Bin*. Molecular hybrid design, synthesis, in vitro and in vivo anticancer evaluation, and mechanism of action of N-acylhydrazone linked, heterobivalent β-carbolines, Bioorganic Chemistry 2020, 96, 103612
4.孙跃,霍新玉,王兆旭,韩小强,张洁*.苯并咪唑桥连的双-β-咔啉衍生物的合成与生物活性,精细化工,2020,08,1672-1677
5.Xiaofei Chen,Liang Guo,Qin Ma,Wei Chen,Wenxi Fan,Jie Zhang *, Design, Synthesis, and Biological Evaluation of Novel N-Acylhydrazone Bond Linked Heterobivalent β-Carbolines as Potential Anticancer Agents, Molecules 2019, 24, 2950
6.XinYu Huo, Liang Guo, XiaoFei Chen, YueTing Zhou, Jie Zhang *,XiaoQiang Han,* Bin Dai *,Design, Synthesis, and Antifungal Activity of Novel Aryl-1,2,3-Triazole-Carboline Hybrids, Molecules 2018, 23, 1344
7.Huo Xinyu, Li Wenbin, Zhang Boya, Chen Xiaofei, Zhou Yueting, Zhang Jie*,Han Xiaoqiang*, Dai Bin, Synthesis and Fungicidal Evaluation of Novelβ-Carboline-Benzimidazole and β-Carboline-Benzothiazole Hybrids, Chin. J. Org. Chem. 2018, 38, 3356-3362 DOI: 10.6023/cjoc201805053
8.Yueting Zhou, Chunjuan Wang, Fang Xin, Xiaoqiang Han*, Jie Zhang*, Ke Sun, Synthesis, Insecticidal, Fungicidal Activities and Structure–Activity Relationships of Tschimganin Analogs, Molecules 2018, 23, 1473
9.Xiaocong Sun, Feng Liu, Xueyuan Yang, Jinghan Wang, Bangjian Dong, Chunfeng Xie, Da-Qing Jin, Jie Zhang***, Dongho Lee, Yasushi Ohizumie, Jing Xu**, Yuanqiang Guo*. Seco-labdane diterpenoids from the leaves of Callicarpa nudiflora showing nitric oxide inhibitory activity, Phytochemistry, 2018, 149 : 31–41
10.周昌健, 谢建伟*, 张洁*, 代斌, 大黄酸-氨基酸缀合物的合成及初步抗肿瘤活性研究, 有机化学, 2017, 37(1): 122 ~ 132
11.张洁, 杜广芬, 顾承志*, 代斌, 氮杂环卡宾催化的氰基甲酸乙酯与醛亚胺的Strecker反应研究, 有机化学, 2017, 37(4): 914 ~ 919.
12.张洁, 周昌健, 谢建伟*, 代斌, 大黄酸-缬氨酸加合物的合成及初步抗肿瘤活性, 高等学校化学学报, 2016, (12): 2159 ~ 2167
13.Jie Zhang, Ying Wang, Guangfen Du, Cheng-Zhi Gu*, Bin Dai, N-Heterocyclic Carbene-Catalysed Direct Synthesis of Cyano Esters via Cyanation- Esterification Reaction of α-Keto Esters, Chinese Journal of Chemistry, 2015, 33(10): 1211 ~ 1215
14.Zihao Li, Nannan Yan, Jianwei Xie*, Ping Liu, Jie Zhang*, Bin Dai, Efficient Copper-Catalyzed Annulation of 2-Formylazoles with 2-Haloanilines for the Synthesis of Pyrrole- and Imidazole-Fused Quinoxalines, Chinese Journal of Chemistry, 2015, 33(5): 589 ~ 593
15.Fei Song, Bin Dai, Haiyan Zhang, Jianwei Xie, Cheng-Zhi Gu, Jie Zhang*, Two new cucurbitane-typetriterpenoid saponins isolated from ethyl acetate extract of Citrullus colocynthis fruit, Journal of Asian Natural Products Research, 2015, 17(8): 813 ~ 818
16.Jie Zhang, GuangFen Du, YueKe Xu, Lin He*, Bin Dai*. N-Heterocyclic Carbene Catalyzed Cyanation Reaction of Carbonyl Compounds with Ethyl Cyanoformate and Acetyl Cyanide, Tetrahedron Letters, 2011, 52(52): 7153 ~ 7156
发明专利:
1. 一种吲哚类化合物及其制备方法、应用,发明专利,张洁,专利号: ZL202010292093.5 (已转让)
2. 一种6-取代-β-咔啉碱类化合物及衍生物的制备方法、应用,发明专利,张洁,专利号: ZL202010436655.9
3. 一种β-咔啉杂合咪唑类化合物及其制备方法、应用,发明专利,张洁,专利号: ZL202110142794.5